Vitamin D2 vs. D3: What’s the Difference? (2024)

You can get vitamin D3 from sun exposure and meat, such as fish oil and egg yolk. You can get vitamin D2 from plants.

Vitamin D is more than just one vitamin. It’s a family of nutrients that shares similarities in chemical structure.

In your diet, the most commonly found members are vitamin D2 and D3. While both types help you meet your vitamin D requirements, they differ in a few important ways.

Research even suggests that vitamin D2 is less effective than vitamin D3 at raising blood levels of vitamin D.

This article sums up the main differences between vitamin D2 and D3.

Vitamin D is a fat-soluble vitamin that promotes the absorption of calcium, regulates bone growth and plays a role in immune function.

Your skin produces vitamin D when it’s exposed to sunlight. However, if you spend most of your time indoors or live at a high latitude, you’ll need to get this vitamin from your diet.

Good dietary sources include fatty fish, fish oils, egg yolk, butter and liver.

However, it may be difficult to get adequate amounts of this vitamin from your diet alone, as rich natural sources are rare. For these reasons, it’s common for people to not get enough.

Luckily, many food manufacturers add it to their products, especially milk, margarine and breakfast cereals. Supplements are also popular.

To prevent deficiency symptoms, make sure to eat vitamin D-rich foods regularly, get some sunlight or take supplements.

Since vitamin D is fat-soluble, it is better to choose oil-based supplements or take them with food that contains some fat (1).

The vitamin comes in two main forms:

  • Vitamin D2 (ergocalciferol)
  • Vitamin D3 (cholecalciferol)

Their differences are discussed in detail below.

Summary Vitamin D is a
fat-soluble vitamin that exists in two main forms: vitamin D2 (ergocalciferol)
and vitamin D3 (cholecalciferol).

Vitamin D3 Comes from Animals, Vitamin D2 from Plants

The two forms of vitamin D differ depending on their food sources.

Vitamin D3 is only found in animal-sourced foods, whereas D2 mainly comes from plant sources and fortified foods.

Sources of Vitamin D3

  • Oily fish and fish oil
  • Liver
  • Egg yolk
  • Butter
  • Dietary supplements

Sources of Vitamin D2

  • Mushrooms (grown in UV light)
  • Fortified foods
  • Dietary supplements

Since vitamin D2 is cheaper to produce, it’s the most common form in fortified foods.

Summary Vitamin D3 is only
found in animals, while vitamin D2 comes from plant-sourced foods.

Vitamin D3 Is Formed in Your Skin

Your skin makes vitamin D3 when it’s exposed to sunlight.

Specifically, ultraviolet B (UVB) radiation from sunlight triggers the formation of vitamin D3 from the compound 7-dehydrocholesterol in skin (2).

A similar process takes place in plants and mushrooms, where UVB light leads to the formation of vitamin D2 from ergosterol, a compound found in plant oils (3).

If you regularly spend time outdoors, lightly clad and without sunscreen, you may be getting all the vitamin D you need.

In Indian people, an estimated half an hour of midday sun twice a week provides the adequate amount (4).

Just keep in mind that this duration of exposure does not apply in countries farther away from the equator. In these countries, you may need more time to achieve the same results.

Nevertheless, be careful not to spend too much time in the sun without sunscreen. This is especially important if you have light-colored skin. Sunburns are a major risk factor for skin cancer (5).

Unlike dietary vitamin D, you cannot overdose on vitamin D3 produced in your skin. If your body already has enough, your skin simply produces less.

That said, many people get very little sun. They either work indoors or live in a country that doesn’t get much sunlight during the winter. If this applies to you, make sure to regularly eat plenty of food rich in vitamin D.

Summary Your skin produces
vitamin D3 when you spend time in the sun. In contrast, vitamin D2 is produced
by plants and mushrooms exposed to sunlight.

Vitamin D3 Is More Effective at Improving Vitamin D Status

Vitamin D2 and D3 are not equal when it comes to raising your vitamin D status.

Both are effectively absorbed into the bloodstream. However, the liver metabolizes them differently.

The liver metabolizes vitamin D2 into 25-hydroxyvitamin D2 and vitamin D3 into 25-hydroxyvitamin D3. These two compounds are collectively known as calcifediol.

Calcifediol is the main circulating form of vitamin D, and its blood levels reflect your body’s stores of this nutrient.

For this reason, your health care provider can estimate your vitamin D status by measuring your levels of calcifediol (6).

However, vitamin D2 seems to yield less calcifediol than an equal amount of vitamin D3.

Most studies show that vitamin D3 is more effective than vitamin D2 at raising blood levels of calcifediol (7, 8).

For example, one study in 32 older women found that a single dose of vitamin D3 was nearly twice as effective as vitamin D2 at raising calcifediol levels (9).

If you are taking vitamin D supplements, consider choosing vitamin D3.

Summary Vitamin D3 appears to
be better than D2 at improving vitamin D status.

Vitamin D2 Supplements Might Be Lower Quality

Scientists have raised concerns that vitamin D2 supplements might be lower quality than D3 supplements.

In fact, studies suggest vitamin D2 is more sensitive to humidity and fluctuations in temperature. For this reason, vitamin D2 supplements may be more likely to degrade over time (10).

However, whether this is relevant to human health is unknown. Also, no studies have compared the stability of vitamin D2 and D3 dissolved in oil.

Until new research proves otherwise, you shouldn’t worry about the quality of your vitamin D2 supplements. Simply make sure to store your supplements in a closed container, at room temperature, in a dry place and out of direct sunlight.

Summary Vitamin D2 supplements
may be more likely to degrade during storage. However, it’s unknown whether the
same applies to oil-based vitamin D2. More studies are needed to examine the
relevance of this to human health.

How to Improve Your Vitamin D Status

Fortunately, there are many ways you can improve your vitamin D status.

Below are a few ideas:

  • Select
    mushrooms that have been exposed to ultraviolet light (11)
  • Take
    fish oil supplements such as cod liver oil
  • Eat
    fatty fish twice a week (12)
  • Choose
    milk or orange juice that’s been fortified with vitamin D
  • Eat
    some eggs and butter (13)
  • Spend
    at least half an hour in the sun daily, if possible

If you take vitamin D supplements, make sure not to exceed the safe upper intake level, which is 4,000 IU (100 micrograms) per day for adults (14).

According to the US Institute of Medicine, the recommended daily allowance is 400–800 IU (10–20 micrograms), but common supplemental doses range from 1,000–2,000 IU (25–50 micrograms) per day.

For detailed information on the optimal dosage of vitamin D, read this article.

Summary You can increase your
vitamin D levels by regularly eating foods rich in vitamin D and spending time
in the sun.

The Bottom Line

Vitamin D is not a single compound but a family of related nutrients. The most common dietary forms are vitamins D2 and D3.

The D3 form is found in fatty animal-sourced foods, such as fish oil and egg yolk. Your skin also produces it in response to sunlight or ultraviolet light. In contrast, vitamin D2 comes from plants.

Interestingly, vitamin D3 appears to be more effective at increasing levels of vitamin D in the blood. Although, scientists debate the relevance of this to human health.

To maintain adequate vitamin D levels, make sure to regularly eat plenty of foods rich in vitamin D or spend some time in the sun. If you take supplements, vitamin D3 is probably your best choice.

Vitamin D2 vs. D3: What’s the Difference? (2024)

FAQs

Vitamin D2 vs. D3: What’s the Difference? ›

Both play the same role in the body, but vitamins D2 and D3 have slightly different molecular structures. The main difference is that vitamin D2 comes from plants, whereas D3 comes from animals, including people. Scientists are not sure yet if one is better than the other for human health.

Which is better, vitamin D2 or D3? ›

Studies have repeatedly shown that vitamin D3 is superior at raising levels of vitamin D in the body. These findings were supported by a recent review of the evidence which found that vitamin D3 supplementation increased vitamin D levels in the body better than vitamin D2.

Why did my doctor prescribe vitamin D2 instead of D3? ›

They usually prescribe vitamin D2 because it is more widely available and less expensive than vitamin D3. 6 That said, higher doses of D3 are available in OTC supplements, so talk to your healthcare provider about supplementing if you prefer D3 over D2.

What is vitamin D2 used for? ›

A form of vitamin D that helps the body use calcium and phosphorus to make strong bones and teeth. It is fat-soluble (can dissolve in fats and oils) and is found in plants and yeast. It can be made in the body from another form of vitamin D when the body is exposed to the sun.

Is it OK to take vitamin D2 everyday? ›

Taken in appropriate doses, vitamin D is generally considered safe. However, taking too much vitamin D in the form of supplements can be harmful. Children age 9 years and older, adults, and pregnant and breastfeeding women who take more than 4,000 IU a day of vitamin D might experience: Nausea and vomiting.

Who should not take vitamin D2? ›

You should not take ergocalciferol if you have had an allergic reaction to vitamin D, or if you have: high levels of vitamin D in your body (hypervitaminosis D); high levels of calcium in your blood (hypercalcemia); or. any condition that makes it hard for your body to absorb nutrients from food (malabsorption).

Can I take 5000 IU of vitamin D3 every day? ›

Although 4,000 IU (100 mcg) is set as the maximum amount of vitamin D you can take safely, several studies have shown that taking up to 10,000 IU (250 mcg) daily is not more likely to cause side effects than lower doses ( 48 , 49 ).

Can I take vitamin D3 and D2 together? ›

As there don't appear to be any negative interactions between the two forms of D, the answer is “yes,” you can take them together.

Is 50,000 units of vitamin D2 a lot? ›

Typical dosing for Vitamin D2 (ergocalciferol)

Hypoparathyroidism: The typical dose ranges between 50,000 and 200,000 units (or international units, IU) by mouth every day, along with calcium supplementation.

What are signs of low vitamin D? ›

What are the symptoms of vitamin D deficiency?
  • Muscle pain.
  • Bone pain.
  • Increased sensitivity to pain.
  • A tingly, “pins-and-needles” sensation in the hands or feet.
  • Muscle weakness in body parts near the trunk of the body, such as the upper arms or thighs.
  • Waddling while walking, due to muscle weakness in the hips or legs.

Is vitamin D2 anti inflammatory? ›

It has been confirmed that vitamin D has potent anti-inflammatory properties. It contributes to reduction in pro-inflammatory mediators and an increase in anti-inflammatory cytokines. There is also evidence that vitamin D could decrease C-reactive protein (CRP) and affect selected haematological indices.

Does vitamin D2 give you energy? ›

Can vitamin D give you more energy? Low energy or fatigue is a common symptom of vitamin D deficiency. That's because vitamin D seems to help mitochondria—the part of a cell that generates energy—use oxygen and power various parts of the body, including muscles.

How do you know if you need vitamin D2? ›

"Most patients with vitamin D deficiency are asymptomatic, however if you're exhausted, your bones hurt, you have muscle weakness or mood changes, that's an indication that something may be abnormal with your body," says Dr. Lacey. Symptoms of vitamin D deficiency may include: Fatigue. Not sleeping well.

Why vitamin D2 is better than D3? ›

Vitamin D3 is more effective in raising vitamin D levels in your bloodstream for a longer period than vitamin D2. On the other hand, vitamin D2 is sourced from plants, and vitamin D3 is derived from animals. If you prefer a plant-based product, vitamin D2 is a better choice for you.

Who should not take vitamin D3? ›

Caution is advised if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

How soon will I feel better after taking vitamin D2? ›

In general, some individuals may start to notice improvements in their Vitamin D levels within a few weeks of starting supplementation, while for others, it may take a bit longer. It's essential to be patient and consistent with your supplement regimen to allow your body to absorb and utilize Vitamin D effectively.

Should I take vitamin D2 and D3 at the same time? ›

Ultimately both vitamin D2 and D3 get converted through enzymatic reactions in the liver and kidneys to the active form of vitamin D and can be taken together [1]. So, in simple terms, the answer is YES! You can take vitamin D and D3 together.

What is the best form of vitamin D to take? ›

Two forms of vitamin D are available in supplements: vitamin D3 and vitamin D2. Both can help correct vitamin D deficiency, but most doctors recommend D3 because it is slightly more active and therefore slightly more effective. Vitamin D3 is naturally produced by animals, including humans.

Is vitamin D2 or D3 better for osteoporosis? ›

Clinical trials have shown vitamin D3 to be more efficient that vitamin D2 in reducing falls and fractures [3]Bischoff-Ferrari, H.A., et al., Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials.

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